Novel target to kill CLL

Novel target to kill CLL.

In this issue of Blood, Liu et al report on OSU-T315, a new agent that specifically disrupts the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway and shows high proapoptotic activity against chronic lymphocytic leukemia (CLL) cells, which may indicate a potential therapeutic application in this disease

Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL.

Previous studies showed that chronic lymphocytic leukemia (CLL) cells exhibit certain mitochondrial abnormalities including mtDNA mutations, increased superoxide generation, and aberrant mitochondrial biogenesis, which are associated with impaired apoptosis and reduced sensitivity to fludarabine. Here we report that CLL cells and multiple myeloma cells are highly sensitive to brefeldin A, an in...

Die to kill: psychological and sociological study of suicide terrorism

One of the principal challenges now days, especially in the countries which are engaged in inland riots, is suicide attack which spreads fear broadly in human societies. More than the legal and political reactions to this social phenomenon, one of the preventive ways, is to analyze the suicide terrorists personally. No doubt, achievement to this understanding can be influential in preventing th...

DNA vaccines and apoptosis: to kill or not to kill?

The Journal of Clinical Investigation | July 2003 | Volume 112 | Number 1 RNase. Proc. Natl. Acad. Sci. U. S. A. 100:4102-4107. 14. Shinkura, R., et al. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:435–441. 15. Yu, K., Chedin, F., Hsieh, C.L., Wilson, T.E., and Lieber, M.R. 2003. R-loops at immunoglobulin class switch regions in the ch...

Do genes allow inflammation to kill or not to kill?